Regulation of Hormone Secretion
- Negative feedback limits secretion when a hormone's physiologic effect has been achieved.
- Insulin lowers blood glucose by increasing cellular glucose uptake, so the resulting fall in glucose reduces further insulin release.
- Positive feedback amplifies a process until a defined endpoint is reached.
- Negative feedback stabilizes a variable by opposing change, whereas positive feedback amplifies a process until a separate event stops the loop.
- Estrogen produces positive feedback before ovulation, creating an LH surge that further supports ovarian estrogen secretion.
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