Myofibroblasts
- Myofibroblasts are contractile connective-tissue cells that resemble fibroblasts but contain more actin and myosin.
- Mesenchymal cells give rise to myofibroblasts.
- Vimentin, caldesmon, and cytokeratins are proteins found in myofibroblasts.
- Fibroblast resemblance reflects the matrix-associated role and shape of myofibroblasts.
- Greater actin and myosin content gives myofibroblasts contractile ability.
- Wound healing uses myofibroblast contraction to pull tissue edges closer together.
- Wound defect reduction occurs when myofibroblasts contract and shrink the open damaged area.
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