Nonerythroid Cells
- Nonerythroid cells are cells that are not red blood cells.
- The nonerythroid cytoskeleton uses several proteins to connect the plasma membrane to actin-based support structures.
- Fodrin is a spectrin-like cytoskeletal protein in nonerythroid cells.
- Actin, and possibly fodrin, serves as the nonerythroid counterpart of spectrin.
- Alpha-actinin cross-links actin filaments.
- Cross-linking means connecting separate filaments into a stronger network.
- An actin meshwork is a network of linked actin filaments.
- Alpha-actinin helps form an actin meshwork by cross-linking actin filaments.
- Vinculin is a linking protein that binds alpha-actinin and talin.
- Talin is a linking protein that attaches to integrins in the plasma membrane.
- The vinculin-talin-integrin connection helps link the actin cytoskeleton to the plasma membrane.
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